Pope Eugene I, also known as Eugenius I, was Pope from 10 August 654 to his death in 657. He was a native of Rome, born to one Rufinianus.
In June 653, in the midst of a dispute with Byzantine Emperor Constans II over Monothelitism (the belief that Jesus had that only a single, divine will), Pope Martin I was seized and carried to Constantinople and subsequently exiled to Cherson in the Crimea. Initially, in the pontiff's absence, the church was probably governed by the archpriest, archdeacon and the primicerius of the notaries. Over a year later, and with no sign of Martin's return, Eugene was chosen to succeed. If the emperor expected Eugene to take a different approach from that of his predecessor, he was disappointed.