Elizabeth de Vere, Countess of Derby, Lord of Mann, was an English noblewoman and the eldest daughter of the Elizabethan courtier, poet, and playwright Edward de Vere, 17th Earl of Oxford.
She was the Lord of Mann from 1612 to 1627, and prior to holding the title, she had taken over many administrative duties appertaining to the Isle of Man's affairs. Elizabeth was the first female to rule as the island's head of state. By tradition, the title is "Lord" even if the ruler is female (one later exception was Queen Victoria, who was Lady of Mann).
She served as a Maid of Honour to Queen Elizabeth I of England before her marriage to William Stanley, 6th Earl of Derby. Their wedding is one of eleven that have been suggested as the inspiration for William Shakespeare's A Midsummer Night's Dream, and the occasion of the play's first performance.