Claudine or Claudia was Lady regnant of Monaco between 1457 and 1458, and then Lady consort of Monaco as spouse of Lord Lambert of Monaco. She was the only child of her father, Catalan Grimaldi, and thereby his heir. At his death, her father stated in his will that she should marry her cousin to ensure that the Grimaldi family should keep the throne of Monaco.
She became Lady of Monaco at her father's death in 1457. Being a minor, she was under the regency of her paternal grandmother, Pomelline Fregoso. After only one year of reign, she abdicated (1458) in favour of her cousin Lambert, her future spouse. In 1465, seven years after her abdication, she married Lambert and became Lady of Monaco as his spouse.
Upon Lambert's death in 1494, their son Jean became Lord of Monaco as Jean II. Claudine outlived Jean, who was murdered in 1505 by his brother Lucien, the subsequent lord. Claudine died in 1515 during Lucien's reign.